- News
- Scientific projects
- Grid computing
- Decrypthon program
- Role-players
- Partners
- Thierry Lhermitte godfather
Results of the first Decrypthon
To promote the use of the Decrypthon platform, the AFM launched a call for proposals in 2003, according to the usual proceedings.
Four research projects were selected and received funding provided they use the platform.
Two groups from the “Département des Sciences de la Vie du Commissariat à l'Energie Atomique” in Saclay (S Zinn-Justin and R Guerois) associated with A. Poupon, from the CNRS (Yeast Structural Genomics Laboratory, Orsay University) aimed to elucidate the structure-function relationships of yeast and human proteins involved in the maintenance of the genomic integrity of the nucleus. Their research has resulted in two publications:
i) Coeytaux K and Poupon A. Prediction of unfolded segments in a protein sequence based on amino acid composition. Bioinformatics, 2005, 21, 1891-1900
ii) Charier G, and al. Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding. Structure, 2004, 9, 1551-1562
Three teams form the IGBMC in Illkirch: J Laporte and J-L Mandel, A Pujol and J-L Mandel, G Bey, F Sirockin, F Plewniak and O Poch have proposed 3 projects with increasing complexity:
Four research projects were selected and received funding provided they use the platform.
Two groups from the “Département des Sciences de la Vie du Commissariat à l'Energie Atomique” in Saclay (S Zinn-Justin and R Guerois) associated with A. Poupon, from the CNRS (Yeast Structural Genomics Laboratory, Orsay University) aimed to elucidate the structure-function relationships of yeast and human proteins involved in the maintenance of the genomic integrity of the nucleus. Their research has resulted in two publications:
i) Coeytaux K and Poupon A. Prediction of unfolded segments in a protein sequence based on amino acid composition. Bioinformatics, 2005, 21, 1891-1900
ii) Charier G, and al. Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding. Structure, 2004, 9, 1551-1562
Three teams form the IGBMC in Illkirch: J Laporte and J-L Mandel, A Pujol and J-L Mandel, G Bey, F Sirockin, F Plewniak and O Poch have proposed 3 projects with increasing complexity:
- The first project, at the proteome level, concerned the identification and characterisation of myotubularins, proteins involved in several neuromuscular diseases, as well as the prediction of protein domains and tissue-specific functions.
The research has resulted in two publications:
i) J Laporte et J-L Mandel : Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases. Hum Mol Genet. 2003, 12 Spec No 2:R285-292
ii) Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells - J Biol Chem. 2004,279:7304-7312.
i) J Laporte et J-L Mandel : Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases. Hum Mol Genet. 2003, 12 Spec No 2:R285-292
ii) Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells - J Biol Chem. 2004,279:7304-7312.
- The second project concerned the analysis of proteins from a cellular organite, the peroxisome, which is implied in some major metabolic functions. This research has resulted in one publication:
i) A Pujol and J-L Mandel, The evolutionary origin of peroxisomes: an ER-peroxisome connection. Mol Biol Evol. 2006; 23:838-485.
- The third project, at the organism level, consisted in the identification of new potential therapeutic targets in Vibrio cholerae and Diabac organisms (diarrhoeal bacteria) implied in diarrhoeal pathologies.
